Mounjaro (tirzepatide) is the newest and most powerful weight loss injection available in South Africa. Clinical trials show average weight loss of 20–22% of body weight — significantly more than Ozempic. If you've heard about this drug and want to understand whether it's right for you, this guide covers everything.
Important Medical Disclaimer: Mounjaro is a prescription medication available only through a licensed doctor. Never use prescription medication without medical supervision. This article is for educational purposes only.
What is Mounjaro (Tirzepatide)?
Mounjaro is a dual-acting GIP/GLP-1 receptor agonist developed by Eli Lilly. While Ozempic only targets one hormone pathway (GLP-1), Mounjaro targets two:
- GLP-1 (Glucagon-like peptide-1): Reduces appetite, slows digestion, regulates blood sugar
- GIP (Glucose-dependent insulinotropic polypeptide): Enhances fat breakdown, improves insulin sensitivity
This dual action is why Mounjaro produces more dramatic weight loss than single-pathway drugs like Ozempic or Saxenda.
Mounjaro Weight Loss Results
From the landmark SURMOUNT clinical trials:
- At the 5mg dose: average 15% body weight loss over 72 weeks
- At the 10mg dose: average 19.5% body weight loss
- At the 15mg dose: average 20.9% body weight loss
- 1 in 3 participants lost 25%+ of their body weight
For a person weighing 100kg, that's up to 20kg of weight loss over about 18 months.
Mounjaro vs Ozempic: Which is Better?
| Feature | Mounjaro (Tirzepatide) | Ozempic (Semaglutide) |
|---|---|---|
| Mechanism | GIP + GLP-1 (dual) | GLP-1 only |
| Average weight loss | 15–22% | 10–15% |
| Injection frequency | Once weekly | Once weekly |
| Approx. SA cost/month | R3,500–R5,500 | R2,500–R4,000 |
| Medical aid coverage | Limited (type 2 diabetes) | Limited (type 2 diabetes) |
Mounjaro Side Effects
Most side effects are gastrointestinal and typically reduce after the first few weeks:
- Nausea (most common, especially at the start)
- Diarrhoea or constipation
- Decreased appetite
- Vomiting
- Abdominal discomfort
- Fatigue
Serious but rare side effects include pancreatitis, gallbladder problems, and kidney issues. Seek immediate medical attention if you experience severe abdominal pain.
Who Qualifies for Mounjaro in South Africa?
Your doctor may prescribe Mounjaro if you:
- Have a BMI of 30+ (obese), or
- Have a BMI of 27+ with a weight-related condition (type 2 diabetes, high blood pressure, high cholesterol)
- Have tried lifestyle changes without sufficient results
Use our BMI Calculator to check your current BMI.
Diet Tips While on Mounjaro
Mounjaro significantly reduces appetite, but eating well amplifies results:
- Eat small, frequent meals — large meals may cause nausea
- Prioritise protein at every meal to preserve muscle mass
- Stay well hydrated — at least 2 litres of water daily
- Avoid greasy, spicy, or very rich foods especially in the first month
- Eat slowly and chew thoroughly
How to Get Mounjaro in South Africa
- Visit your GP or an obesity specialist / endocrinologist
- Discuss your weight history and health conditions
- Get a prescription (Mounjaro is a Schedule 4 medication in SA)
- Fill the prescription at a pharmacy (Clicks, Dis-Chem, or independent pharmacies)
- Check medical aid formularies — some Discovery and Momentum plans cover it for T2 diabetes
Conclusion
Mounjaro represents a step-change in weight loss medication. With clinical results that rival bariatric surgery in some patients, it offers real hope for South Africans struggling with obesity. However, it's expensive, requires a prescription, and works best alongside a healthy diet and lifestyle. Talk to your doctor to find out if it's right for you.
Related articles: Ozempic for Weight Loss | Semaglutide Comparison | GLP-1 Drug Guide | Check Your BMI